Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Galnon (TFA) | 1217448-19-5 | MFCD06798339 | 98.9% | 792.84 g·mol⁻¹ | C42H47F3N4O8 | 25 MG
Galnon TFA is a selective, non-peptide agonist of the galanin receptors GAL1 and GAL2, with reported Ki values of 11.7 μM (GAL1) and 34.1 μM (GAL2). It is used in in vitro and in vivo research to study galanin receptor pharmacology and has demonstrated anticonvulsant and anxiolytic effects.
- Selective galanin receptor agonist with reported Ki values (GAL1 = 11.7 μM, GAL2 = 34.1 μM).
- Non-peptide small-molecule ligand suitable for receptor pharmacology studies.
- Demonstrated anticonvulsant and anxiolytic activity in preclinical studies.
- Supplied at high purity (98.88%) for research use.
- Available in small research-scale quantities, including 25 mg.
![eMolecules bis(2,2,2-trifluoroacetic acid);2-(2,2,2-trifluoroethyl)-2,6-diazaspiro[3.3]heptane | 1810069-99-8 | MFCD29037458 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502158414.JPG-250.jpg)
eMolecules bis(2,2,2-trifluoroacetic acid);2-(2,2,2-trifluoroethyl)-2,6-diazaspiro[3.3]heptane | 1810069-99-8 | MFCD29037458 | 1g
Pharmablock | bis(2,2,2-trifluoroacetic acid);2-(2,2,2-trifluoroethyl)-2,6-diazaspiro[3.3]heptane | 1g | 551248906 | PBLJ3135-1 | | 1810069-99-8 | MFCD29037458 | 408.221 | C11H13F9N2O4
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Selleck Chemical LLC Z-LEHD-FMK TFA
Z-LEHD-FMK TFA (Caspase-9 Inhibitor) is a cell-permeable competitive and irreversible inhibitor of enzyme caspase-9 which helps in cell survival
Medchemexpress LLC FTI-2153 (TFA) | 2820151-01-5 | 99.1% | 580.62 g/mol | C27H31F3N4O5S | 10MM 1ML
FTI-2153 TFA is the trifluoroacetic acid salt of a potent farnesyltransferase inhibitor supplied for research use. It is provided as a ready-to-use 10 mM solution in DMSO (1 mL) and in solid amounts, with supporting datasheet, SDS, and COA for characterization and safe handling.
Medchemexpress LLC Lys-bradykinin TFA | 00-00-0 | 99.9% | 1188.38 g/mol (free base) | C56H85N17O12 · xC2HF3O2 | 25 MG
Lys-bradykinin TFA is the trifluoroacetate salt form of the decapeptide kallidin (Lys-bradykinin). It is used as a research reagent and acts as a ligand for kallidin and bradykinin receptors, supporting studies in vascular regulation, inflammation, and pain signaling.
- TFA salt form of lys-bradykinin (kallidin).
- High purity (≈99.85%).
- Molecular weight 1188.38 g/mol (free base).
- Provided in small quantities suitable for biochemical assays; 25 mg size available.
- Intended for receptor binding and vascular biology research applications.
Medchemexpress LLC CH-0793076 TFA (TP3076 TFA) | 2740278-76-4 | 98.7% | 572.53 g·mol⁻¹ | C28H27F3N4O6 | 5 MG
CH-0793076 TFA is a camptothecin-like hexacyclic analog and the active metabolite of TP300 that functions as a DNA topoisomerase I inhibitor. It is supplied as a trifluoroacetate salt for research use and has demonstrated antiproliferative activity, including activity against cells expressing BCRP.
- Inhibits DNA topoisomerase I (reported IC50 ≈ 2.3 μM).
- Active metabolite of TP300.
- Demonstrates antiproliferative activity in cellular assays.
- Provided as a trifluoroacetate salt suitable for biochemical studies.
- Molecular weight 572.53 g·mol⁻¹; chemical formula C28H27F3N4O6.
Medchemexpress LLC 3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid | 909725-62-8 | 98.2% | 456.39 g/mol | C18H28F3N2O6P | 1 ML
W146 TFA is the trifluoroacetic acid salt of W146, a selective antagonist of the sphingosine-1-phosphate receptor 1 (S1PR1). It is supplied as a ready-to-use 10 mM solution in DMSO and as solid material for research applications, and is used in in vitro pharmacology and signaling studies to probe S1PR1-mediated pathways.
- Selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1).
- Reported EC50 of 398 nM.
- Supplied as 10 mM solution in DMSO (1 mL) and in multiple solid masses.
- Chemical identifiers: CAS 909725-62-8, formula C18H28F3N2O6P, MW 456.39 g/mol.
- Intended for research use only; not for human or clinical use.
Apexbio Technology LLC FSLLRY-NH2 TFA 245329-02-6 (free base) 10mg
FSLLRY-NH2 TFA is a synthetic peptide antagonist targeting protease-activated receptor 2 (PAR-2) It is designed to block PAR-2 activation thereby inhibiting intracellular signaling cascades such as calcium mobilization and MAP kinase activation that underlie inflammatory responses nociceptive transmission and immune modulation FSLLRY-NH2 TFA exerts its biological activity primarily through competitive binding to PAR-2 preventing receptor activation and downstream signaling events Based on these pharmacological properties FSLLRY-NH2 TFA holds research potential in the study of inflammation-associated disorders and pain pathways
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic acid ReagentPlus, 99, 76-05-1, MFCD00004169
Trifluoroacetic acid ReagentPlus, 99
Apexbio Technology LLC 5-hme-CTP 10x100ul (100 mM)
5-hme-CTP (5-hydroxymethylcytidine triphosphate) is a modified cytidine triphosphate bearing a hydroxymethyl group at the 5-position carbon This modification can enhance RNA stability and functionality During in vitro mRNA synthesis 5-hme-CTP can be incorporated into RNA molecules producing RNA containing 5-hydroxymethylcytidine Hydroxymethyl-modified RNA plays an essential role in studying RNA structure function and RNA-protein interactions Additionally 5-hme-CTP significantly improves RNA stability by reducing its intracellular degradation Thus this modified nucleotide has broad applications in gene expression research RNA-based drug development and gene therapy
Medchemexpress LLC LY117018 TFA 25mg | 2390041-98-0 | 25 MG
LY117018 TFA is a raloxifene analog and a selective estrogen receptor modulator (SERM) reported to exert antiproliferative effects on breast cancer cell lines. Supplied as a trifluoroacetate salt, the compound is provided as a small-scale research reagent for in vitro studies.
- Selective estrogen receptor modulator activity.
- Reported antiproliferative effects on breast cancer cell lines.
- Supplied as a trifluoroacetate salt for improved handling.
- Available in milligram-scale quantities for research use.
- Chemical formula C29H26F3NO6S; molecular weight 573.58 g/mol.